Nurofen Plus may cause dizziness light-headedness or drowsiness in some people. If this occurs, do not drive or operate machinery. If you drink alcohol, dizziness, light-headedness and/or drowsiness may be worse. Drinking alcohol More instructions can be found in Section 4. How do I use Nurofen Plus? in the full CMI. 5. What should I know while using Nurofen Plus? Things you should do For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI.

In patients aged between 12 - 18 years in whom respiratory function might be compromised, including post tonsillectomy and/or adenoidectomy for obstructive sleep apnoea, due to an increased risk of developing serious and life-threatening adverse reactions (see Section 4.4 Special Warnings and Precautions for Use, Paediatric use).Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines. 7. Product details Women who are pregnant. Ibuprofen may increase the risk of miscarriage and malformations and should not be used during the first and second trimesters of pregnancy unless considered essential by your doctor. Ibuprofen must not be taken in the third trimester because it may delay labour, increase the length of labour and cause complications in the newborn baby. For the temporary relief of acute moderate pain and inflammation in patients over the age of 12 years. 4.2 Dose and Method of Administration Physical dependence, which can occur after several days to weeks of continued opioid usage, results in withdrawal symptoms if the opioid is ceased abruptly or the dose is significantly reduced. Withdrawal symptoms can also occur following the administration of an opioid antagonist (e.g. naloxone) or partial agonist (e.g. buprenorphine). Severe hepatic impairment (see Section 4.4 Special Warnings and Precautions for Use, Use in hepatic impairment).

have or have had asthma, diabetes, high cholesterol, high blood pressure, a stroke, heart, liver, kidney or bowel problems or are dehydrated.Patients with uncontrolled hypertension, congestive heart failure (NYHA II-III), established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease should only be treated with ibuprofen after careful consideration and high doses (2400 mg/day) should be avoided. Respiratory depression. Serious, life-threatening or fatal respiratory depression can occur with the use of opioids even when used as recommended. It can occur at any time during the use of Nurofen Plus but the risk is greatest during initiation of therapy or following an increase in dose. Patients should be monitored closely for respiratory depression at these times. possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses; COX is involved in making substances in the body known as prostaglandins, in response to injury and in certain diseases and conditions. The prostaglandins cause pain, swelling and inflammation. Ibuprofen reduces inflammation and pain by reducing the production of these prostaglandins.

Active, or a history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding). As with other non-steroidal anti-inflammatory agents, ibuprofen should not be used in active gastrointestinal bleeding or in the presence of peptic ulceration. The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation (see section 4.3), and in the elderly. These patients should commence treatment on the lowest dose available. Ibuprofen also brings down a fever by reducing the production of prostaglandins. Fever is associated with an increase in prostaglandins in the brain, which cause the body temperature to increase. By reducing prostaglandins in the brain, ibuprofen lowers body temperature. Nurofen also offer products which claim to treat specific areas, so if you’re looking for something specifically to target a tension headache or period pain, opting for a product that will specifically work on your problem area could be beneficial for you. First signs are: fever, sore throat, superficial mouth ulcers, flu-like symptoms, severe exhaustion, unexplained bleeding and bruising.Some medicines may interfere with Nurofen Plus and affect how it works. A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI. 4. How do I use Nurofen Plus? Nurofen Joint & Muscular Pain Relief 200mg Medicated Plaster, For pain relief of muscular strains or sprains close to the joint of the upper or lower limb. Contain ibuprofen.